Treprostinil
货号：
10162-10mg 基本售价：
8848.0 元 规格：
10 mg
产品信息
概述| 货号 | 10162-10mg |
| 描述 | Primary pulmonary hypertension (PPH) is a condition of unknown cause that is characterized by increasing pulmonary arterial and vascular resistance. Treprostinil is a stable analog of prostacyclin (Item No. 18220) that is used clinically for the treatment of PPH under the trade name Remodulin™. The structural modifications in treprostinil compared to prostacyclin increase the plasma half-life from 2 minutes to 34 and 85 minutes for intravenous and subcutaneous infusion of the drug, respectively.1 In addition to treprostinil’s direct vasodilatory effects, it also inhibits inflammatory cytokine (TNFα, IL-1β, IL-6, GM-CF) production by human alveolar macrophages in the sub-micromolar range by preventing NF-κB translocation to the nucleus.2 |
| 别名 | BW 15AU;LRX 15;Rumodolin;U-62840;Uniprost; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Olschewski, H.,Rose, F.,Schermuly, R., et al. Prostacyclin and its analogues in the treatment of pulmonary hypertension. Pharmacology & Therapeutics 102, 139-153 (2004).
2.Raychauduri, B.,Malur, A.,Bonfield, T.L., et al. The prostacyclin analogue treprostinil blocks NFκB nuclear translocation in human alveolar macrophages. The Journal of Biological Chemisty 277(36), 33344-33348 (2002).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 390.5 |
| 分子式 | C23H34O5 |
| CAS号 | 81846-19-7 |
| 稳定性 | ≥ 2 years |
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