BAY 60-7550
货号：
10011135-10mg 基本售价：
8848.0 元 规格：
10 mg
产品信息
概述| 货号 | 10011135-10mg |
| 描述 | The second messengers cAMP and cGMP are important mediators of signal transduction and hence a wide range of cellular processes including vasodilation and synaptic plasticity. Type 2 cyclic nucleotide phosphodiesterases (PDE2) isoforms inactivate cAMP and cGMP by hydrolyzing the phosphodiester bond. BAY 60-7550 is a potent PDE2 inhibitor with IC50 values of 2.0 nM (bovine) and 4.7 nM (human).1 It is 50-fold more selective for PDE2 compared to PDE1 and greater than 100-fold selective compared to PDE5 PDE3B, PDE4B, PDE7B, PDE8A, PDE9A, PDE10A, and PDE11A.1 At 3 mg/kg BAY 60-7550 antagonizes oxidative stress-induced anxiety-like behavioral effects in mice by increasing cGMP signaling.2 At 1 mg/kg BAY 60-7550 improves the performance of rats in an object location task, enhancing cAMP/cGMP-mediated object and spatial memory consolidation.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Boess, F.G.,Hendrix, M.,van der Staay, F.J., et al. Inhibition of phosphodiesterase 2 increases neuronal cGMP, synaptic plasticity and memory performance. Neuropharmacology 47, 1081-1092 (2004).
2.Masood, A.,Nadeem, A.,Mustafa, S.J., et al. Reversal of oxidative stress-induced anxiety by inhibition of phosphodiesterase-2 in mice. Journal of Pharmacology and Experimental Therapeutics 326(2), 369-379 (2008).
3.Rutten, K.,Van Donkelaar, E.L.,Ferrington, L., et al. Phosphodiesterase inhibitors enhance object memory independent of cerebral blood flow and glucose utilization in rats. Neuropsychopharmacology (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 476.6 |
| 分子式 | C27H32N4O4 |
| CAS号 | 439083-90-6 |
| 稳定性 | ≥ 2 years |
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