(E/Z)-Endoxifen
货号：
21502-25mg 基本售价：
8820.0 元 规格：
25 mg
产品信息
概述| 货号 | 21502-25mg |
| 描述 | (E/Z)-Endoxifen is an active metabolite of tamoxifen (Item No. 13258) produced by the sequential action of cytochrome P450 (CYP) isoforms, including CYP2D6.1,2,3 It is a strong anti-estrogen, as it has an approximately 100-fold greater affinity for estrogen receptors than tamoxifen.1 As the efficient conversion of tamoxifen to endoxifen depends on CYP2D6, polymorphisms in this CYP isoform can impact the effectiveness of TMX treatment.1,2,3 |
| 别名 | (E/Z)-N-desmethyl-4-hydroxy Tamoxifen; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Brauch, H.,Mürdter, T.E.,Eichelbaum, M., et al. Pharmacogenomics of tamoxifen therapy. Clin. Chem. 55(10), 1770-1782 (2009).
2.Mugundu, G.M.,Sallans, L.,Guo, Y., et al. Assessment of the impact of CYP3A polymorphisms on the formation of α-hydroxytamoxifen and N-desmethyltamoxifen in human liver microsomes. Drug Metabolism and Disposition 40(2), 389-396 (2012).
3.Markopoulos, C.,Kykalos, S., and Mantas, D. Impact of CYP2D*6 in the adjuvant treatment of breast cancer patients with tamoxifen. World J. Clin. Oncol. 5(3), 374-381 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% (mixture of isomers) |
| 计算分子量 | 373.5 |
| 分子式 | C25H27NO2 |
| CAS号 | 110025-28-0 |
| 稳定性 | ≥ 2 years |
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