Bazedoxifene acetate
货号：
15005-50mg 基本售价：
8820.0 元 规格：
50 mg
产品信息
概述| 货号 | 15005-50mg |
| 描述 | Bazedoxifene acetate is a third generation selective estrogen receptor modulator (SERM). It is an indole-based ER ligand that binds to both ERα (IC50 = 26 nM) and ERβ (IC50 = 99 nM).1 Bazedoxifene actetate antagonizes 17β-estradiol-dependent MCF-7 and T47D breast cancer cell proliferation in vitro as well as hormone-independent growth of MCF-7:5C cells that are resistant to long-term estrogen deprivation (80% reduction with 10 nM).2 It has been shown to arrest cell cycling by downregulating cyclin D1 and ERα.2 |
| 别名 | TSE 424;Viviant; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Komm, B.S.,Kharode, Y.P.,Bodine, P.V.N., et al. Bazedoxifene acetate: A selective estrogen receptor modulator with improved selectivity. Endocrinology 146(9), 3999-4008 (2005).
2.Lewis-Wambi, J.S.,Kim, H.,Curpan, R., et al. The selective estrogen receptor modulator bazedoxifene inhibits hormone-independent breast cancer cell growth and down-regulates estrogen receptor α and cyclin D1. Mol. Pharmacol. 80(4), 610-620 (2011).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 530.7 |
| 分子式 | C30H34N2O3 • C2H4O2 |
| CAS号 | 198481-33-3 |
| 稳定性 | ≥ 2 years |
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