| 货号 | 14765-10mg |
| 描述 | Sulprostone is a metabolism resistant synthetic analog of PGE2.1 It is a selective agonist for EP3 receptors with a Ki value of 0.35 nM at the human recombinant EP3-III receptor and an IC50 of 0.01 µM for the inhibition of PGE2binding.2,3 Sulprostone is a potent stimulator of uterine smooth muscle contractions with high abortifacient activity.4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Schaaf, T.K.,Bindra, J.S.,Eggler, J.F., et al. N-(methanesulfonyl)-16-phenoxyprostaglandincarboxamides: Tissue-selective, uterine stimulants. Journal of Medicinal Chemistry 24, 1353-1359 (1981). 2.Abramovitz, M.,Adam, M.,Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochimica et Biophysica Acta 1483, 285-293 (2000). 3.Negishi, M.,Harazono, A.,Sugimoto, Y., et al. TEI-3356, a highly selective agonist for the prostaglandin EP3 receptor. Prostaglandins 48, 275-283 (1994). 4.Schillinger, E.,Prior, G.,Speckenbach, A., et al. Receptor binding in various tissues of PGE2, and sulprostone, a novel PGE2-derivative. Prostaglandins 18, 293-302 (1979). 5.Krishna, U.,Gupta, A.N.,Ma, H.K., et al. Randomized comparison of different prostaglandin analogues and laminaria tent for preoperative cervical dilation. Contraception 34, 237-251 (1986). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 465.6 |
| 分子式 | C23H31NO7S |
| CAS号 | 60325-46-4 |
| 稳定性 | ≥ 2 years |
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