| 货号 | 19082-50ug |
| 描述 | Convulxin is a toxin that was first isolated from rattlesnake venom. It activates the collagen receptor glycoprotein VI (GPVI) on platelets and initiates blood clotting.1,2 Convulxin is used to study signaling through GPVI and to characterize platelet function.3,4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Vargaftig, B.B.,Prado-Francheschi, J.,Chignard, M., et al. Activation of guinea-pig platelets induced by convulxin, a substance extracted from the venom of Crotalus durissus cascavella. European Journal of Pharmacology 68(4), 451-464 (2016). 2.Jandrot-Perrus, M.,Lagrue, A.H.,Okuma, M., et al. Adhesion and activation of human platelets induced by convulxin involve glycoprotein VI and integrin α2β1. The Journal of Biological Chemisty 272(43), 27035-27041 (1997). 3.Chatterjee, M.S.,Denney, W.S.,Jing, H., et al. Systems biology of coagulation initiation: Kinetics of thrombin generation in resting and activated human blood. PLoS Computational Biology 6(9), (2010). 4.Casari, C.,Berrou, E.,Lebret, M., et al. von Willebrand factor mutation promotes thrombocytopathy by inhibiting integrin αIIbβ3. Journal of Clinical Investigation 123(12), 5071-5081 (2013). 5.van Bladel, E.R.,Laarhoven, A.G.,van der Heijden, L.B., et al. Functional platelet defects in children with severe chronic ITP as tested with 2 novel assays applicable for low platelet counts. Blood 123(10), 1556-1563 (2014). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| CAS号 | 37206-04-5 |
| 稳定性 | ≥ 2 years |
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