ICI 216140
货号：
17479-5mg 基本售价：
8750.0 元 规格：
5 mg
产品信息
概述| 货号 | 17479-5mg |
| 描述 | Bombesin is a peptide, originally isolated from the skin of the European fire-bellied toad, with pressor and sympathoexcitatory activity. Its three receptors are distributed throughout the central and peripheral nervous system and are involved in gastric acid secretion, emotional response, temperature control, learning, and memory. Neuromedin B and gastrin-releasing peptide (GRP) are mammalian homologs of bombesin.1 ICI 216140 is a GRP/bombesin receptor 2 antagonist (IC50 = 2 nM in vitro).2 At 2 mg/kg, it can reduce bombesin-stimulated pancreatic amylase secretion in rats.2 At 1 mM, it has been shown to attenuate bombesin-stimulated increases in blood pressure in rats.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Gonzaelz, N.,Moody, T.W.,Igarashi, H., et al. Bombesin-related peptides and their receptors: Recent advances in their role in physiology and disease states. Curr.Opin.Endrocrinol.Diabetes Obes. 15(1), 58-64 (2008).
2.Camble, R.,Cotton, R.,Dutta, A.S., et al. N-isobutyryl-His-Trp-Ala-Val-D-Ala-His-Leu-NHMe (ICI 216140) a potent in vivo antagonist analogue of bombesin/gastrin releasing peptide (BN/GRP) derived from the C-terminal sequence lacking the final methionine residue. Life Sciences 45(17), 1521-1527 (1989).
3.Zogovic, B., and Pilowsky, P.M. Intrathecal bombesin is sympathoexcitatory and pressor in rat. American Journal of Physiology.Regulatory, Integrative and Comparative Physiology 301(5), R1486-R1494 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 916.1 |
| 分子式 | C45H65N13O8 |
| CAS号 | 124001-41-8 |
| 稳定性 | ≥ 2 years |
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