PF-477736
货号：
17859-50mg 基本售价：
8736.0 元 规格：
50 mg
产品信息
概述| 货号 | 17859-50mg |
| 描述 | Checkpoint kinase 1 (Chk1) regulates S and G2-M phase cell cycle checkpoints in response to DNA damage. PF-477736 is an ATP-competitive inhibitor of Chk1 with a Ki value of 0.49 nM that demonstrates 100-fold selectivity over Chk2.1 When used in combination with various chemotherapeutics, PF-477736 abrogates DNA damage-induced cell cycle arrest, potentiating the antiproliferative effects of these compounds in tumor cell lines and xenografts.1,2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Blasina, A.,Hallin, J.,Chen, E., et al. Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1. Molecular Cancer Therapeutics 7(8), 2394-2404 (2008).
2.Zhang, C.,Yan, Z.,Painter, C.L., et al. PF-00477736 mediates checkpoint kinase 1 signaling pathway and potentiates docetaxel-induced efficacy in xenografts. Clinical Cancer Research 15(14), 4630-4640 (2009).
3.Nguyen, T.,Hawkins, E.,Kolluri, A., et al. Synergism between bosutinib (SKI-606) and the Chk1 inhibitor (PF-00477736) in highly imatinib-resistant BCR-ABL+ leukemia cells. Leukemia Research 39, 65-71 (2015).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 419.5 |
| 分子式 | C22H25N7O2 |
| CAS号 | 952021-60-2 |
| 稳定性 | ≥ 2 years |
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