| 货号 | 17482-5mg |
| 描述 | The atypical protein kinase C isoform, PKCζ, is critical for mediating mitogenic signal transduction, cell survival, and some of the physiological actions of insulin.1 PKCζ pseudosubstrate inhibitor is a synthetic peptide that corresponds to a pseudosubstrate domain of this PKC isoform.2 It selectively, reversibly, and substrate-competitively inhibits PKCζ activity and, thus, is used to delineate the signaling functions of PKCζ.3,4,5 |
| 别名 | Protein Kinase Cζ Pseudosubstrate Inhibitor; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Toker, A. Signaling through protein kinase C. Frontiers in Bioscience 3, d1134-d1147 (1998). 2.Eichholtz, T.,de Bont, D.B.A.,de Widt, J., et al. A myristoylated pseudosubstrate peptide, a novel protein kinase C inhibitor. The Journal of Biological Chemisty 268(3), 1982-1986 (1993). 3.Lee, A.W. The role of atypical protein kinase C in CSF-1-dependent Erk activation and proliferation in myeloid progenitors and macrophages. PLoS One 6(10), e25580 (2011). 4.Dang, P.M.C.,Fontayne, A.,Hakim, J., et al. Protein kinase C ζ phosphorylates a subset of selective sites of the NADPH oxidase component p47phox and participates in formyl peptide-mediated neutrophil respiratory burst. Journal of Immunology 166, 1206-1213 (2001). 5.Standaert, M.L.,Galloway, L.,Karnam, P., et al. Protein kinase C-ζ as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport. The Journal of Biological Chemisty 272(48), 30075-30082 (1997). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 1718 |
| 分子式 | C76H128N30O16 |
| CAS号 | 799764-07-1 |
| 稳定性 | ≥ 2 years |
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