5-trans U-46619
货号：
16452-10mg 基本售价：
8736.0 元 规格：
10 mg
产品信息
概述| 货号 | 16452-10mg |
| 描述 | U-46619 is a TP receptor agonist that exhibits properties similar to Thromboxane A2, inducing platelet aggregation and vascular smooth muscle contraction.1,25-trans U-46619 is a minor impurity (2-5%) which is variably present in most commercial preparations of U-46619. The biological activity of 5-trans U-46619 has rarely been tested separately from U-46619 itself. In the only case published to date, 5-trans U-46619 was found to be a about half as potent an inhibitor of Prostaglandin E synthase as the 5-cis version of U-46619.3 |
| 别名 | 5,6-transU-46619; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Liel, N.,Mais, D.E. and Halushka, P.V. Binding of a thromboxane A2/prostaglandin H2 agonist [3H]U46619 to washed human platelets. Prostaglandins 33, 789-797 (1987).
2.Coleman, R.A.,Humphrey, P.P.A.,Kennedy, I., et al. Comparison of the actions of U-46619, a prostaglandin H2-analogue, with those of prostaglandin H2 and thromboxane A2 on some isolated smooth muscle preparations. British Journal of Pharmacology 73, 773-778 (1981).
3.Quraishi, O.,Mancini, J.A. and Riendeau, D. Inhibition of inducible prostaglandin E2 synthase by 15-deoxy-Δ12,14-prostaglandin J2 and polyunsaturated fatty acids. Biochemical Pharmacology 63, 1183-1189 (2002).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 350.5 |
| 分子式 | C21H34O4 |
| CAS号 | 330796-58-2 |
| 稳定性 | ≥ 1 year |
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