| 货号 | 5770/50 |
| 别名 | 2-[(4-Methoxy-2-naphthalenyl)amino] |
| 供应商 | Tocris |
| 生物活性 | Potent TMEM16A (Anoctamin-1) blocker (IC50 = 80 nM). Exhibits >100-fold selectivity for TMEM16A over bestrophin-1, CLC2 and CFTR. Induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 338.31 |
| 分子式 | C18H14N2O5 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Boedtkjeret al (2015) New selective inhibitors of calcium-activated chloride channels - T16A(inh) -A01, CaCC(inh) -A01 and MONNA - what do they inhibit? Br.J.Pharmacol. 172 4158. PMID: 26013995. Ohet al (2013) MONNA, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1. Mol.Pharmacol. 84 726. PMID: 23997117. |