| 货号 | 1366/50 |
| 别名 | 1-(2-Naphthalenyl)-2-propen-1-one |
| 供应商 | Tocris |
| 生物活性 | Potent, selective inhibitor of Janus tyrosine kinase 3 (JAK3) which binds competitively to the JAK3 ATP site. pIC50 values are 6.8, 5.0, 4.7, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively. Inhibits STAT-5 phosphorylation and T cell proliferation. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 182.22 |
| 分子式 | C13H10O |
| CAS号 | 4452-06-6 |
| 参考文献 | Orangeet al (2011) IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function. J.Clin.Invest. 121 1535. PMID: 21383498. Brownet al (2000) Naphthyl ketones: a new class of janus kinase 3 inhibitors Bioorg.Med.Chem.Lett. 10 575. PMID: 10741557. |