| 货号 | 3591/50 |
| 别名 | (OC-6-45)-Aqua(3-hydroxy-2-pyridine |
| 供应商 | Tocris |
| 生物活性 | Potent inhibitor of PTEN (phosphatase and tensin homolog) (IC50 = 35 nM). Displays selectivity for PTEN over cysteine-based phosphatases such as SopB, MTM, PTPβ and SAC (IC50 values are 588 nM, 4.03, 57.5 and >10 μM respectively). Increases PIP2 and PIP3 levels; also increases Akt translocation in NIH/3T3 fibroblasts. Blocks the immunosuppressant activity of IDO-activated Tregs. Promotes antitumor inflammatory response in combination with immunotherapy and enhances anticancer chemotherapy in tumor-bearing mice. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 361.16 |
| 分子式 | C12H10N2O8 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Sharmaet al (2015) The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment. Sci.Adv. 1 e1500845. PMID: 26601142. Rosivatzet al (2006) A small-molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN). ACS Chem.Biol. 1 780. PMID: 17240976. |