| 货号 | 2734/50 |
| 别名 | 6,7-Dimethyl-2,4-di-1-pyrrolidinyl- |
| 供应商 | Tocris |
| 生物活性 | Positive allosteric modulator of GABAA receptors. Enhances GABA-induced Cl- currents in the α1β2γ2,α3β2γ2andα6β2γ2 subtypes. Causes sedation in vivo following i.v. administration without losing "righting reflex". Also displays antioxidant activity. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 321.85 |
| 分子式 | C16H23N5.HCl |
| 可溶性/溶解性 | Soluble to 25 mM in water and to 50 mM in DMSO |
| CAS号 | 157013-32-6 |
| 参考文献 | Rohnet al (1996) Inhibition of Ca2+-pump ATPase and the Na+/K+-pump ATPase by iron-generated free radicals. Biochem.Pharmacol. 51 471. PMID: 8619892. Bundyet al (1995) Synthesis of novel 2,4-diaminopyrrolo-[2,3-d]pyrimidines with antioxidant, neuroprotective, and antiasthma activity. J.Med.Chem. 38 4161. PMID: 7473542. Haesooket al (1995) U-89843A is a novel allosteric modulator of γ-aminobutyric acidA receptors. J.Pharmacol.Exp.Ther. 275 1390. PMID: 8531107. |