| 货号 | 5063/50 |
| 别名 | N-[2-(1-Piperidinyl)-5-(trifluorome |
| 供应商 | Tocris |
| 生物活性 | Selective serine arginine protein kinase (SRPK) 1 inhibitor (Ki = 0.89 μM). Inhibits SRPK2 at higher concentrations. Does not significantly inhibit other SRPKs such as CLK1 and CLK4, or other classes of SR kinases. Down-regulates expression of VEGF165 but does not affect VEGF165bexpression. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 349.35 |
| 分子式 | C18H18F3N3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl |
| 参考文献 | Gammonset al (2013) SRPK1 inhibition modulates VEGF splicing to reduce pathological neovascularization in a rat model of retinopathy of prematurity. Invest.Ophthalmol.Vis.Sci. 54 5797. PMID: 23761094. Olteanet al (2012) SRPK1 inhibition in vivo: modulation of VEGF splicing and potential treatment for multiple diseases. Biochem.Soc.Trans. 40 831. PMID: 22817743. Fukuharaet al (2006) Utilization of host SR protein kinases and RNA-splicing machinery during viral replication. Proc.Natl.Acad.Sci.USA 103 11329. PMID: 16840555. |