| 货号 | 1804/50 |
| 别名 | 2-[[3-(2-Quinolinylmethoxy)phenyl]a |
| 供应商 | Tocris |
| 生物活性 | Potent and selective competitive leukotriene D4 and E4 receptor antagonist. Inhibits LTD4- but not histamine-induced guinea pig ileum and trachea contraction (pA2 = 8.7). Also inhibits LTD4-attenuation of human PMN chemotaxis. Orally active in vivo. |
| 运输条件 | Ambient |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 406.87 |
| 分子式 | C23H18N2O3.HCl |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| CAS号 | 105350-26-3 |
| 参考文献 | Boucheloucheet al (1990) LTD4 increases cytosolic free calcium and inositol phosphates in human neutrophils: inhibition by the novel LTD4 receptor antagonist, SR2640, and possible relation to modulation of chemotaxis. Agents Actions 29 299. PMID: 2160189. Thomsen and Ahnfelt-Ronne (1989) Inhibition by the LTD4 antagonist, SR2640, of effects of LTD4 on canine polymorphonuclear leukocyte functions. Biochem.Pharmacol. 38 2291. PMID: 2546563. Ahnfelt-Ronneet al (1988) A novel leukotriene D4/E4 antagonist, SR2640 (2-[3-(2-quinolylmethoxy)phenylamino]benzoic acid). Eur.J.Pharmacol. 155 117. PMID: 2854067. |