| 货号 | 0985/50 |
| 别名 | (N-[2-(2-Cyclopropylmethoxyphenoxy) |
| 供应商 | Tocris |
| 生物活性 | α1A-adrenoceptor antagonist, with very high affinity for α1A receptors (pKi and pA2 estimates of 9.1 - 9.9) and a 30 - 100 fold selectivity over the α1Bandα1D subtypes (pKi and pA2 estimates 7.7 - 7.8). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 计算分子量 | 449.42 |
| 分子式 | C24H29N2O2Cl.HCl |
| 可溶性/溶解性 | Soluble to 10 mM in ethanol and to 50 mM in DMSO |
| CAS号 | 169505-93-5 |
| 参考文献 | Fordet al (1996) RS 17053 (N-[2-(2-cyclopropylmethoxyphenoxy)ethyl]-5-chloro-α,α-dimethyl-1H-indole-3-ethanamine hydrochloride, a selective α1A-adrenoceptor antagonist, displays low affinity for functional α1-adrenoceptors in human prostate: implications for adrenoceptor classification. Mol.Pharmacol. 49 209. PMID: 8632751. Marshallet al (1996) Different subtypes of α1A-adrenoceptor mediating contraction of rat epididymal vas deferens, rat hepatic portal vein and human prostate distinguished by the antagonist RS 17053. Br.J.Pharmacol. 119 407. PMID: 8886428. Fordet al (1995) Do α1A(α1C)-adrenoceptors (AR) mediate prostatic smooth muscle contraction in man? Studies with a novel, selective α1A-AR antagonist, RS 17053. Br.J.Pharmacol. 114C25. |