| 货号 | 1842/50 |
| 别名 | O,O'-[1,6-Hexanediylbis(iminocarbony |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of diacylglycerol lipase (IC50 values are 1.1 and 4 μM in rat cardiac myocytes and canine platelets respectively). Weakly inhibits phospholipases C and A2. Potentiates acetylcholine evoked relaxation in mesenteric arteries by the inhibition of cholinesterase activity (IC50 = 4 μM). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >95 % |
| 计算分子量 | 394.51 |
| 分子式 | C20H34N4O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| CAS号 | 83654-05-1 |
| 参考文献 | Ghisdalet al (2005) The diacylglycerol lipase inhibitor RHC-80267 potentiates the relaxation to acetylcholine in rat mesenteric artery by anti-cholinesterase action. Eur.J.Pharmacol. 517 97. PMID: 15958263. Suzukiet al (2002) Effects of RHC-80267, an inhibitor of diacylglycerol lipase, on excitation of circular smooth muscle of the guinea-pig gastric antrum. J.Smooth Muscle Res. 38 153. PMID: 12713022. Sutherland and Amin (1982) Relative activities of rat and dog platelet phospholipase A2 and diglyceride lipase. J.Biol.Chem. 257 14006. PMID: 7142192. |