| 货号 | 1213/50 |
| 别名 | 2-(2-Amino-3-methoxyphenyl)-4H-1-be |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of mitogen-activated protein kinase kinase (MKK / MEK). Acts by binding to the inactivated form of MEK, thereby preventing its phosphorylation by cRAF or MEK kinase (IC50 = 2-7 μM). Inhibits cell growth and proliferation in acute myelogenous leukemia (AML) cell lines; causes G1 arrest by blocking p53-dependent p21 induction. Enhances embryonic stem cell self-renewal. Also available as part of the MAPK Cascade Inhibitor Tocriset™ and MAPK Inhibitor Tocriset™. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 267.28 |
| 分子式 | C16H13NO3 |
| 可溶性/溶解性 | Soluble to 25 mM in DMSO and to 5 mM in ethanol |
| CAS号 | 167869-21-8 |
| 参考文献 | Kojimaet al (2007) Mitogen-activated protein kinase kinase inhibition enhances nuclear proapoptotic function of p53 in acute myelogenous leukemia cells. 67 3210. PMID: 17409429. Qiet al (2004) BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways. Proc.Natl.Acad.Sci.USA 101 6027. PMID: 15075392. Tsanget al (1998) Effects of mitogen-activated protein kinase kinase inhibitor PD 98059 on antigen challenge of guinea-pig airways in vitro. Br.J.Pharmacol. 125 61. PMID: 9776345. Alessiet al (1995) PD 98059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitroandin vivo. J.Biol.Chem. 270 27489. PMID: 7499206. Dudleyet al (1995) A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc.Natl.Acad.Sci.U.S.A. 92 7686. PMID: 7644477. |