| 货号 | 1037/50 |
| 别名 | 4-[(3-Bromophenyl)amino]-6,7-dimeth |
| 供应商 | Tocris |
| 生物活性 | An extremely potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase, with an IC50 of 25 pM. Inhibits other purified tyrosine kinases only at micromolar or higher concentrations. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 计算分子量 | 396.67 |
| 分子式 | C16H14BrN3O2.HCl |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO with gentle warming |
| CAS号 | 153436-54-5 |
| 参考文献 | Boset al (1997) PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner. Clin.Cancer Res. 3 2099. PMID: 9815602. Bridgeset al (1996) Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor. J.Med.Chem. 39 267. PMID: 8568816. Fryet al (1994) A specific inhibitor of the epidermal growth factor receptor tyrosine kinase. Science 265 1093. PMID: 8066447. |