| 货号 | 1508/50 |
| 别名 | 2-Chloro-5-nitro-N-phenylbenzamide |
| 供应商 | Tocris |
| 生物活性 | Selective PPARγ antagonist (IC50 values are 3.3, 32 and 2000 nM for PPARγ, PPARα and PPARδ respectively). Blocks the inhibition of osteoclast formation induced by IL-4 in the low micromolar range (1-2 μM), therefore is more potent than BADGE (Cat. No. 1326). Anticancer, inhibits growth of human mammary tumor cell lines. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 276.68 |
| 分子式 | C13H19N2O3Cl |
| 可溶性/溶解性 | Soluble to 25 mM in ethanol with gentle warming and to 100 mM in DMSO |
| CAS号 | 22978-25-2 |
| 参考文献 | Seargentet al (2004) GW9662, a potent antaognist of PPARγ, inhibits growth of breast tumour cells and promotes the anticancer effects of the PPARγ agonist rosiglitazone, independently of PPARγ activation. Br.J.Pharmacol. 143 933. PMID: 15533890. Leesnitzeret al (2002) Functional consequences of cysteine modification in the ligand binding sites of peroxisone proliferator activated receptors by GW9662. Biochemistry 41 6640. PMID: 12022867. Bendixenet al (2001) IL-4 inhibits osteoclast formation through a direct action on osteoclast precursors via peroxisome proliferator-activated receptor γ1. Proc.Natl.Acad.Sci.U.S.A. 98 2443. PMID: 11226258. |