| 货号 | 2473/50 |
| 别名 | 3-[2-[2-Chloro-4-[[3-(2,6-dichlorop |
| 供应商 | Tocris |
| 生物活性 | Selective, non-steroidal farnesoid X receptor (FXR) agonist (EC50 = 15 nM). Displays no activity at other nuclear receptors at concentrations up to 1 μM. Improves hyperglycaemia and hyperlipidemia in diabetic db/db mice. Shown to suppress autophagy in nutrient-deprived mouse hepatocytes. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >97 % |
| 计算分子量 | 542.84 |
| 分子式 | C28H22Cl3NO4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 10 mM in ethanol |
| CAS号 | 278779-30-9 |
| 参考文献 | Leeet al (2014) Nutrient-sensing nuclear receptors coordinate autophagy. Nature 516 112. PMID: 25383539. Cariouet al (2006) The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice. J.Biol.Chem. 281 11039. PMID: 16446356. Zhanget al (2006) Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. Proc.Natl.Acad.Sci.USA 1031006. Maloneyet al (2000) Identification of a chemical tool for the orphan nuclear receptor FXR. J.Med.Chem. 43 2971. PMID: 10956205. |