| 货号 | 1099/50 |
| 别名 | [3R-(3α,4aβ,5β,6β,6aα,10α,10aβ,10bα)]-5-(Ac |
| 供应商 | Tocris |
| 生物活性 | Cell-permeable activator of adenylyl cyclase. Hypotensive and vasodilatory agent. Induces neuronal differentiation in stem cells and in several neuroblastoma. Used to reprogram mouse embryonic fibroblasts to induced pluripotent stem cells in combination with three other small molecules (Cat. Nos. 3742, 4423 and 4703). Also available as part of the PKA Tocriset™. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 410.51 |
| 分子式 | C22H34O7 |
| 可溶性/溶解性 | Soluble to 10 mM in ethanol and to 25 mM in DMSO |
| CAS号 | 66575-29-9 |
| 参考文献 | Houet al (2013) Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds. 341 651. PMID: 23868920. Kimet al (2005) cAMP induces neuronal differentiation of mesenchymal stem cells via activation of extracellular signal-regulated kinase/MAPK. Neuroreport 16 1357. PMID: 16056139. Laurenzaet al (1989) Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action? TiPS 10 442. PMID: 2692256. Awadet al (1983) Interactions of forskolin and adenylate cyclase. J.Biol.Chem. 258 2960. PMID: 6681815. Seamonet al (1983) Structure-activity relationships for activation of adenylate cyclase by the diterpene forskolin and its derivatives. J.Med.Chem. 26 436. PMID: 6681845. |