| 货号 | 3041/50 |
| 别名 | 2-[(3-Chlorophenyl)methoxy]-6-(1-pi |
| 供应商 | Tocris |
| 生物活性 | Potent and selective 5-HT2C receptor agonist (pEC50 values are 9.96, 7.19 and 6.81 for human 5-HT2C, 5-HT2B and 5-HT2A receptors respectively). Displays antipsychotic activity; suppresses condition avoidance responding (CAR) and inhibits PCP and amphetamine-stimulated hyperactivity in rats following subcutaneous administration. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 341.24 |
| 分子式 | C15H17N4OCl.HCl |
| 可溶性/溶解性 | Soluble to 20 mM in water and to 100 mM in DMSO |
| CAS号 | 479683-64-2 |
| 参考文献 | Jensenet al (2013) Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT2A/5-HT2C receptor agonists with pro-cognitive properties. J.Med.Chem 56 1211. PMID: 23301527. Kalgutkaret al (2007) Genotoxicity of 2-(3-chlorobenzyloxy)-6-(piperazinyl)pyrazine, a novel 5-hydroxytryptamine2c receptor agonist for the treatment of obesity: role of metabolic activation. Drug Metab.Dispos. 35 848. PMID: 17344339. Siuciaket al (2007) CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity. Neuropharmacology 52 279. PMID: 16949622. |