| 货号 | 3299/50 |
| 别名 | 1,1'-[1,4-Phenylenebis-(methylene)]- |
| 供应商 | Tocris |
| 生物活性 | Highly selective CXCR4 chemokine receptor antagonist (IC50 values are 0.02 - 0.13 and > 25 μM for CXCR4 and all other chemokine receptors respectively). Switches inflammatory responses from Th2 to Th1 type and reduces airway hyperresponsiveness in a mouse model of asthma. Potently inhibits HIV-1 and HIV-2 replication in vitro(EC50 = 4 - 35 nM) and mobilizes hematopoietic stem cells in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 794.48 |
| 分子式 | C28H54N8.8HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| 参考文献 | Paganessiet al (2011) Effective mobilization of hematopoietic progenitor cells in G-CSF mobilization defective CD26-/- mice through AMD3100-induced disruption of the CXCL12-CXCR4 axis. Exp.Hematol. 39 384. PMID: 21168468. Hogaboamet al (2005) The therapeutic potential in targeting CCR5 and CXCR4 receptors in infectious and allergic pulmonary disease. Pharmacol.Ther. 107 314. PMID: 16009428. Hatseet al (2002) Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4. FEBS Letts. 527255. Bridgeret al (1995) Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-tetraazamacrocycles that inhibits HIV replication. Effects of macrocyclic ring size and substituents on the aromatic linker. J.Med.Chem. 38 366. PMID: 7830280. |