| 货号 | 1809/50 |
| 别名 | 3-[2-[4-(4-Fluorobenzoyl)-1-piperid |
| 供应商 | Tocris |
| 生物活性 | Potent and selective 5-HT2A receptor antagonist (Ki values are 0.13, 4.55, 40, 62 and 1570 nM at 5-HT2A,α1, 5-HT2C, D2 and 5-HT1A respectively). Centrally active following systemic administration in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 447.95 |
| 分子式 | C22H22FN3O2S.HCl |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO with gentle warming |
| CAS号 | 76330-71-7 |
| 参考文献 | Herthet al (2009) Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET. Bioorg.Med.Chem. 17 2989. PMID: 19329329. Kennettet al (1994) Evidence that 5-HT2C receptor antagonists are anxiolytic in the rat Geller-Seifter model of anxiety. Psychopharmacology 114 90. PMID: 7846211. Koeniget al (1987) Stimulation of corticosterone and β-endorphin secretion in the rat by selective 5-HT receptor subtype activation. Eur.J.Pharmacol. 137 1. PMID: 2956114. Sietnick (1985) Involvement of 5-HT2 receptors in the LSD- and L-5-HTP-induced suppression of lordotic behavior in the female rat. J.Neural Transm. 61 65. PMID: 3872342. |