| 货号 | 2254/50 |
| 别名 | 3-Amino-6-chloro-5-dimethylamino-N- |
| 供应商 | Tocris |
| 生物活性 | Antagonist at the mGlu5 receptor (Ki = 295 nM). Inhibits human mGlu5 receptor-mediated calcium flux with an IC50 of 134 nM. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 329.19 |
| 分子式 | C12H13ClN6O.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 37804-11-8 |
| 参考文献 | Wanget al (2008) Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors. J.Neurosci. 28 4385. PMID: 18434517. Bonnefouset al (2005) Dipyridyl amides: potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists. Bioorg.Med.Chem.Lett. 15 1197. PMID: 15686941. |