| 货号 | 14750-10mg |
| 描述 | 16,16-dimethyl PGE2 is a competitive inhibitor of 15-hydroxy PGDH, but it is not a substrate for the enzyme.1 Because of its resistance to metabolism by 15-hydroxy PGDH, it has a prolonged half-life in vivo. 16,16-dimethyl PGE2 acts as an agonist on most EP receptor subtypes, and has been used experimentally to induce cervical ripening, uterine contraction, and prevent ulceration of the gastric mucosa in rats and dogs.2,3 The Kd for activation of isolated EP2 receptors is about 1 nM.3 16,16-dimethyl PGE2 can be used to preserve the self-renewal properties while preventing the differentiation of hematopoietic stem cells during expansion in culture.4,5 |
| 别名 | 16,16-dimethyl PGE2; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ohno, H.,Morikawa, Y. and Hirata, F. Studies on 15-hydroxyprostaglandin dehydrogenase with various prostaglandin analogues. Journal of Biochemistry 84, 1485-1494 (1978). 2.Robert, A.,Schultz, J.R.,Nezamis, J.E., et al. Gastric antisecretory and antiulcer properties of PGE2, 15-methyl PGE2, and 16,16-dimethyl PGE2. Intravenous, oral and intrajejunal administration. Gastroenterology 70, 359-370 (1976). 3.Coleman, R.A.,Smith, W.L. and Narumiya, S. Classification of prostanoid receptors: Properties, distribution, and structure of the receptors and their subtypes. Pharmacological Reviews 46, 205-229 (1994). 4.Hagedorn, E.J.,Durand, E.M.,Fast, E.M., et al. Getting more for your marrow: Boosting hematopoietic stem cell numbers with PGE2. Experimental Cell Research (2014). 5.Genovese, P.,Schiroli, G.,Escobar, G., et al. Targeted genome editing in human repopulating haematopoietic stem cells. Nature 510(7504), 235-240 (2014). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 380.5 |
| 分子式 | C22H36O5 |
| CAS号 | 39746-25-3 |
| 稳定性 | ≥ 1 year |
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