| 货号 | 16404-25mg |
| 描述 | CMP-Sialic acid is a form of the sugar N-acetylneuraminic acid (Neu5Ac) O-linked with the nucleotide cytidine-5’-monophosphate (CMP). In vertebrates, it is biosynthesized within the nucleus from CTP and Neu5Ac by CMP-sialic acid synthetases.1 Sialyltransferases transfer Neu5Ac from CMP-sialic acid to various acceptor substrates, most commonly at terminal positions of the oligosaccharide component of glycoproteins or glycolipids.2,3 Sialic acid-containing glycans at the cell surface play important roles in cell interactions and have roles in infection, inflammation, and cancer.3,4,5 |
| 别名 | CMP-Neu5Ac; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Münster-Kühnel, A.K.,Tiralongo, J.,Krapp, S., et al. Structure and function of vertebrate CMP-sialic acid synthetases. Glycobiology 14(10), 43R-51R (2004). 2.Tsuji, S. Molecular cloning and functional analysis of sialyltransferases. Journal of Biochemistry 120(1), 1-13 (1996). 3.Audry, M.,Jeanneau, C.,Imberty, A., et al. Current trends in the structure-activity relationships of sialyltransferases. Glycobiology 21(6), 716-726 (2011). 4.Hennet, T. From glycosylation disorders back to glycosylation: What have we learned? Biochim.Biophys.Acta. 1792(9), 921-924 (2009). 5.Samraj, A.N.,Läubli, H.,Varki, N., et al. Involvement of a non-human sialic acid in human cancer. Front.Oncol. 4, 1-13 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥85% |
| 计算分子量 | 636.4 |
| 分子式 | C20H30N4O16P • Na |
| CAS号 | 1007117-62-5 |
| 稳定性 | ≥ 2 years |
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