| 货号 | 16002-5mg |
| 描述 | Sp-8-bromo-cyclic AMPS (Sp-8-bromo-cAMPS) is a cell-permeable, cAMP analog that combines an exocyclic sulfur substitution in the axial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP.1,2 This configuration pools the structural features of two established cyclic-AMP-dependent protein kinase (PKA) activators, 8-bromo-cAMP (Item No. 14431) and Sp-cAMPS (Item No. 14983). Sp-8-bromo-cAMPS is a PKA agonist (EC50 = 1.5 µM) with improved lipophilicity and is not readily degraded by cyclic nucleotide phosphodiesterases.3,4 |
| 别名 | 8-Bromoadenosine 3,5-cyclic Monophosphothioate SP-Isomer;Sp-8-bromo-cAMPS; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Yokozaki, H.,Tortora, G.,Pepe, S., et al. Unhydrolyzable analogues of adenosine 3:5-monophosphate demonstrating growth inhibition and differentiation in human cancer cells. Cancer Research 52(9), 2504-2508 (1992). 2.Dostmann, W.R.,Taylor, S.S.,Genieser, H.G., et al. Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3,5-cyclic phosphorothioates. J. Biol. Chem. 265(18), 10484-10491 (1990). 3.Schwede, F.,Maronde, F.,Genieser, H., et al. Cyclic nucleotide analogs as biochemical tools and prospective drugs. Pharmacology & Therapeutics 87(2), 199-226 (2000). 4.Schaap, P.,van Ments-Cohen, M.,Soede, R.D., et al. Cell-permeable non-hydrolyzable cAMP derivatives as tools for analysis of signaling pathways controlling gene regulation in Dictyostelium. The Journal of Biological Chemisty 268(9), 6323-6331 (1993). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 446.2 |
| 分子式 | C10H10BrN5O5PS • Na |
| CAS号 | 1573115-90-8 |
| 稳定性 | ≥ 2 years |
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