| 货号 | 2175/50 |
| 别名 | (3R,11bR)-rel-1,3,4,6,7,11b-hexahyd |
| 供应商 | Tocris |
| 生物活性 | Potent inhibitor of vesicular monoamine uptake; depletes stores of dopamine, serotonin and noradrenalin. Binds with high affinity (IC50= 3.2 nM) to vesicular monoamine transporter (VMAT) in chromaffin granule membranes and displays higher affinity for VMAT2 than VMAT1. Also reported to block dopamine receptors. Causes behavioral depression; inhibits locomotor activity and produces hypothermia upon systemic administration in rats and mice. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 317.2 |
| 分子式 | C19H27NO3 |
| 可溶性/溶解性 | Soluble to 30 mM in ethanol and to 100 mM in DMSO |
| CAS号 | 58-46-8 |
| 参考文献 | Peteret al (1996) Chimeric vesicular monoamine transporters identify structural domains that influence substrate affinity and sensitivity to tetrabenazine. J.Biol.Chem. 271 2979. PMID: 8621690. Pettiboneet al (1984) Tetrabenazine-induced depletion of brain monoamines: characterisation and interaction with selected antidepressants. Eur.J.Pharmacol. 102 425. PMID: 6489435. Recheset al (1983) Tetrabenazine, an amine-depleting drug, also blocks dopamine receptors in rat brain. J.Pharmacol.Exp.Ther 225 515. PMID: 6864517. Schermanet al (1983) Characterisation of the monoamine carrier of chromaffin granule membrane by binding of [2-3H]dihydrotetrabenazine. Proc.Natl.Acad.Sci.USA 80584. |