| 货号 | 2471/50 |
| 别名 | 10-(3-Aminopropyl)-3,4-dimethyl-9(1 |
| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of Syk kinase. Inhibits tyrosine phosphorylation of Syk initiated by the engagement of FcεRI in rat and human mast cells. Results in the abrogation of degranulation, TNF-α production (IC50 = 10 μM) and other related signaling events. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 396.17 |
| 分子式 | C18H20N2O.C4H4O4 |
| 可溶性/溶解性 | Soluble to 75 mM in water and to 100 mM in DMSO |
| CAS号 | 201010-95-9 |
| 参考文献 | Luskova and Draber (2004) Modulation of the Fcε receptor I signaling by tyrosine kinase inhibitors: search for therapeutic targets of inflammatory and allergy diseases. Curr.Pharm.Des. 10 1727. PMID: 15180535. Moriyaet al (1997) ER-27319, an acridone-related compound, inhibits release of antigen-induced allergic mediators from mast cells by selective inhibition of Fce receptor I-mediated activation of Syk. Proc.Natl.Acad.Sci.USA 9412539. |