| 货号 | 2624/50 |
| 别名 | 4-Amino-1-(2-deoxy-β-D-erythro-pento |
| 供应商 | Tocris |
| 生物活性 | Cytosine analog that once incorporated into DNA acts as a suicide substrate for DNA methyltransferase. Inhibits DNA methyltransferase and results in DNA hypomethylation and activation of silent genes. Chemotherapeutic agent; suppresses growth of human tumor cell lines. Demethylates differentiation-related genes; reverses embryonic stem cell differentiation. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 228.21 |
| 分子式 | C8H12N4O4 |
| 可溶性/溶解性 | Soluble to 50 mM in water and to 50 mM in DMSO |
| CAS号 | 2353-33-5 |
| 参考文献 | Momparler (2005) Pharmacology of 5-aza-2'-deoxycytidine (decitabine). Semin.Hematol. 42 (Suppl 2) S9. PMID: 16015507. Benderet al (1998) Inhibition of DNA methylation by 5-aza-2'-deoxycytidine supresses the growth of human tumour cell lines. Cancer Res. 58 95. PMID: 9426064. Jackson-Grusbyet al (1997) Mutagenicity of 5-aza-2'-deoxycytidine is mediated by the mammalian DNA methyltransferase. Proc.Natl.Acad.Sci.USA 944681. |