| 货号 | 17575-25mg |
| 描述 | Calindol is a phenylalkylamine calcimimetic that facilitates the activation of the calcium-sensing receptor (CaSR), a G protein-coupled receptor that triggers phosphatidylinositol (PI)-intracellular calcium signaling and, in some cell types, cell proliferation.1 It potently stimulates PI hydrolysis and proliferation through human CaSR (pEC50 values are 6.9 and 7.4, respectively) in the presence of calcium.2 Calindol directly interacts with CaSR in transmembrane domains and triggers PI hydrolysis less effectively in the absence of calcium, indicating that it is an allosteric modulator that cooperates with calcium to activate the CaSR.2,3,4 Calindol is used to study the properties and distribution of CaSR in different types of cells and tissues.4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kessler, A.,Faure, H.,Petrel, C., et al. N2-benzyl-N1-(1-(1-naphthyl)ethyl)-3-phenylpropane-1,2-diamines and conformationally restrained indole analogues: Development of calindol as a new calcimimetic acting at the calcium sensing receptor. Bioorganic & Medicinal Chemistry Letters 14(12), 3345-3349 (2004). 2.Ma, J.N.,Owens, M.,Gustafsson, M., et al. Characterization of highly efficacious allosteric agonists of the human calcium-sensing receptor. Journal of Pharmacology and Experimental Therapeutics 337(1), 275-284 (2011). 3.Petrel, C.,Kessler, A.,Dauban, P., et al. Positive and negative allosteric modulators of the Ca2+-sensing receptor interact within overlapping but not identical binding sites in the transmembrane domain. J.Bio.Chem. 279(18), 18990-18997 (2004). 4.Ray, K.,Tisdale, J.,Dodd, R.H., et al. Calindol, a positive allosteric modulator of the human Ca2+ receptor, activates an extracellular ligand-binding domain-deleted rhodopsin-like seven-transmembrane structure in the absence of Ca2+. J.Bio.Chem. 280(44), 37013-37020 (2005). 5.Weston, A.H.,Absi, M.,Ward, D.T., et al. Evidence in favor of a calcium-sensing receptor in arterial endothelial cells: Studies with calindol and Calhex 231. Circulation Research 97(4), 391-398 (2005). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 336.9 |
| 分子式 | C21H20N2 • HCl |
| CAS号 | 729610-18-8 |
| 稳定性 | ≥ 2 years |
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