MS37452
货号：
17533-25mg 基本售价：
8582.0 元 规格：
25 mg
产品信息
概述| 货号 | 17533-25mg |
| 描述 | Chromobox homolog 7 (CBX7) functions through its N-terminal chromodomain, which recognizes histone 3 trimethyl lysine 27 (H3K27me3), to repress gene transcription. It plays a key role in gene transcription in cellular processes related to stem cell self-renewal and differentiation, as well as tumor progression.1 MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 µM).1 At 250 µM, it has been shown to derepress transcription of the polycomb repressive complex target gene p16/CDKN2A in prostate cancer cells.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ren, C.,Morohashi, K.,Plotnikov, A.N., et al. Small-molecule modulators of methyl-lysine binding for the CBX7 chromodomain. Chemistry & Biology 22, 161-168 (2015).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 398.5 |
| 分子式 | C22H26N2O5 |
| CAS号 | 423748-02-1 |
| 稳定性 | ≥ 2 years |
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