BAY 85-3934
货号：
15297-25mg 基本售价：
8582.0 元 规格：
25 mg
产品信息
概述| 货号 | 15297-25mg |
| 描述 | Hypoxia-inducible factor (HIF) is the major transcription factor involved in erythropoietin gene expression. Because oxygen-dependent degradation of the α subunit of HIF suppresses erythropoietin expression, stimulation of erythropoiesis by agents that prevent degradation of HIF has been one strategy for managing anemia.1 BAY 85-3934 stabilizes HIF from degradation in the proteasome by inhibiting HIF-1α prolyl hydroxylase (IC50 = 0.49 µM).2 Inhibition of HIF prolyl hydroxylase by BAY 85-3934 has been shown to increase endogenous production of erythropoietin.2 This compound has been investigated in clinical trial for treatment of patients with anemia associated with chronic kidney disease and/or end-stage renal disease.2 |
| 别名 | Molidustat; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Macdougall, I.C. New anemia therapies: Translating novel strategies from bench to bedside. Am.J.Kidney Dis. 59(3), 444-451 (2012).
2.Thede, K.,Flamme, I.,Oehme, F., et al. Substituted dihydropyrazolones for treating cardiovascular and hematological diseases. 12/447,192, 1-81 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 314 |
| 分子式 | C13H14N8O2 |
| CAS号 | 1154028-82-6 |
| 稳定性 | ≥ 2 years |
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