PF-03814735
货号：
15015-50mg 基本售价：
8582.0 元 规格：
50 mg
产品信息
概述| 货号 | 15015-50mg |
| 描述 | The Aurora kinases are a family of serine/threonine kinases that are key regulators of mitosis and cytokinesis. PF-03814735 is a reversible inhibitor of both Aurora A and B kinases with IC50 values of 0.8 and 5 nM, respectively, in in vitro activity assays.1 PF-03814735 also inhibits the kinases FLT1, FAK, TrkA, Met, and FGFR1 with IC50 values of 10, 22, 30, 100, and 100 nM, respectively.1 PF-03814735 inhibits cell proliferation of HCT116, HL-60, A549, and H125 tumor cell lines with IC50 values ranging from 42-150 nM and shows in vivo efficacy in an HCT116 tumor xenograft mouse model.1 PF-03814735 has been shown to be particularly sensitive towards inhibiting the growth of small cell lung cancer cell lines and other tumors driven by the Myc family genes.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Jani, J.P.,Arcari, J.,Bernardo, V., et al. PF-03814735, an orally bioavailable small molecule aurora kinase inhibitor for cancer therapy. Molecular Cancer Therapeutics 9, 883-894 (2010).
2.Hook, K.E.,Garza, S.J.,Lira, M.E., et al. An integrated genomic approach to identify predictive biomarkers of response to the aurora kinase inhibitor PF-03814735. Molecular Cancer Therapeutics 11(3), 710-719 (2012).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 474.5 |
| 分子式 | C23H25F3N6O2 |
| CAS号 | 942487-16-3 |
| 稳定性 | ≥ 2 years |
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