L-798,106
货号：
11129-50mg 基本售价：
8582.0 元 规格：
50 mg
产品信息
概述| 货号 | 11129-50mg |
| 描述 | Prostaglandin E2 (Item No. 14010) exerts its effects through four separate G-protein coupled receptors (EP1, EP2, EP3, and EP4).1 L-798,106 is a highly selective EP3 receptor antagonist with Ki values of 0.3, 916, >5,000, and >5,000 nM at EP3, EP4, EP1, and EP2, respectively.2 At 0.2 µM, it blocks the EP3 agonist activity of sulprostone (Item No. 14765) on guinea pig vas deferens and trachea.3 |
| 别名 | CM 9;GW 671021; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Coleman, R.A.,Smith, W.L., and Narumiya, S. Classification of prostanoid receptors: Properties, distribution, and structure of the receptors and their subtypes. Pharmacological Reviews 46, 205-229 (1994).
2.Juteau, H.,Gareau, Y.,Labelle, M., et al. Structure-activity relationship of cinnamic acylsulfonamide analogues on the human EP3 prostanoid receptor. Bioorganic & Medicinal Chemistry 9, 1977-1984 (2001).
3.Jones, R.L.,Giembycz, M.A., and Woodward, D.F. Prostanoid receptor antagonists: Development strategies and therapeutic applications. British Journal of Pharmacology 158(1), 104-145 (2009).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 536.4 |
| 分子式 | C27H22BrNO4 |
| CAS号 | 244101-02-8 |
| 稳定性 | ≥ 2 years |
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