| 货号 | 10755-100ug |
| 描述 | Post-translational modification of histones by methylation of lysine residues can promote transcriptional activation or repression. G9a-like protein (GLP) and G9a are SET domain-containing methyltransferases that specifically mono- and di-methylate histone H3 at lysine 9 (H3K9).1,2 Methylation of H3K9 by a GLP/G9a heteromeric complex regulates gene expression by silencing euchromatin.3 GLP and G9a share 80% sequence identity in their SET domains. Structure-activity relationship (SAR) studies have been employed to design potent and selective inhibitors of these proteins, including BIX-01294 and UNC0638, with IC50 values in the nanomolar range.4 |
| 别名 | EHMT1;Euchromatic Histone-Lysine N-Methyltransferase 1;Eu HMTase 1;GLP;KMT1D; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Wu, H.,Min, J.,Lunin, V.V., et al. Structural biology of human H3K9 methyltransferases. PLoS One 5(1), e8570 (2010). 2.Patnaik, D.,Chin, H.G.,Estève, P.O., et al. Substrate specificity and kinetic mechanism of mammalian G9a histone H3 methyltransferase. The Journal of Biological Chemisty 279(51), 53248-53258 (2004). 3.Tachibana, M.,Matsumura, Y.,Fukuda, M., et al. G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription. EMBO Journal 27, 2681-2690 (2008). 4.Chang, Y.,Zhang, X.,Horton, J.R., et al. Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294. Nature Structural & Molecular Biology 16(3), 312-317 (2009). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥95% estimated by SDS-PAGE |
| 稳定性 | ≥ 6 months |
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