| 货号 | 11050-1mg |
| 描述 | The vacuolar H+-ATPase (V-ATPase) is a multisubunit complex that establishes pH gradients along secretory and endocytic pathways by catalyzing ATP hydrolysis via the V1 domain and driving proton translocation through the V0 domain.1 Concanamycin A is a plecomacrolide antibiotic produced by Streptomyces that blocks lysosomal acidification through selective inhibition of the V-type ATPase (EC50 = 2.1-2.3 μM).2,3,4 Concanamycin A blocks cell surface expression of viral glycoproteins without affecting their synthesis and, at 0.8 μM, prevents entry of influenza virus into cells.5 |
| 别名 | Antibiotic X 4357B;NSC 674620;X 4357B; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Huss, M. and Wieczorek, H. Inhibitors of V-ATPases: Old and new players. Journal of Experimental Biology 212, 341-346 (2009). 2.Sobota, J.A.,Bäck, N.,Eipper, B.A., et al. Inhibitors of the V0 subunit of the vacuolar H+-ATPase prevent segregation of lysosomal- and secretory-pathway proteins. Journal of Cell Science 122(19), 3542-3553 (2009). 3.Johnson, R.M.,Allen, C.,Melman, S.D., et al. Identification of inhibitors of V-ATPase pumps in yeast by HTS flow cytometry. Analytical Biochemistry 398(2), 203-211 (2010). 4.Dröse, S. and Altendorf, K. Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases. Journal of Experimental Biology 200, 1-8 (1997). 5.Guinea, R. and Carrasco, L. Requirement for vacuolar proton-ATPase activity during entry of influenza virus into cells. Journal of Virology 69(4), 2306-2312 (1995). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 866.1 |
| 分子式 | C46H75NO14 |
| CAS号 | 80890-47-7 |
| 稳定性 | ≥ 1 year |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |