| 货号 | 13532-10mg |
| 描述 | 17-phenyl trinor PGE2 ethyl amide is derived from 17-phenyl trinor PGE2, a synthetic analog of PGE2 that acts as an agonist of EP1 and EP3 receptors in mice (Ki = 14 and 3.7 nM, respectively) and EP1, EP3, and EP4 in rats (Ki = 25, 4.3, and 54 nM, respectively).1,2 17-phenyl trinor PGE2 causes contraction of guinea pig ileum at a concentration of 11 µM and is 4.4 times more potent than PGE2 as an antifertility agent in hamsters.3,4 Modification of the C-1 carboxyl group to an ethyl amide serves to increase lipid solubility, thereby improving uptake into tissues and further lowering the effective concentration. Ethyl amide groups are then removed by amidases, regenerating the active free acid. |
| 别名 | 17-phenyl trinor PGE2 ethyl amide; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kiriyama, M.,Ushikubi, F.,Kobayashi, T., et al. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. British Journal of Pharmacology 122, 217-224 (1997). 2.Boie, Y.,Stocco, R.,Sawyer, N., et al. Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. European Journal of Pharmacology 340, 227-241 (1997). 3.Lawrence, R.A.,Jones, R.L. and Wilson, N.H. Characterization of receptors involved in the direct and indirect actions of prostaglandins E and I on the guinea-pig ileum. British Journal of Pharmacology 105, 271-278 (1992). 4.Miller, W.L.,Weeks, J.R.,Lauderdale, J.W., et al. Biological activities of 17-phenyl-18,19,20-trinorprostaglandins. Prostaglandins 9, 9-18 (1975). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 413.6 |
| 分子式 | C25H35NO4 |
| CAS号 | 1219032-20-8 |
| 稳定性 | ≥ 1 year |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |