| 货号 | 5994/50 |
| 别名 | 3-(1-Methyl-1H-indol-3-yl)-4-[1-[1- |
| 供应商 | Tocris |
| 生物活性 | Potent PKCβ inhibitor (IC50 values are 6, 39, 83 and 110 nM for PKCβ, PKCα, PKCγ and PKCε, respectively). Suppresses proliferation and induces apoptosis in HCT116 colon carcinoma and U87MG glioblastoma cells in vitro. Reduces tumor growth and exhibits antiangiogenic activity in HT-29 colon carcinoma xenografts in mice. Also suppresses growth of HCT116 and U87MG xenografts in mice. Orally active. |
| 运输条件 | Ambient |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 515.6 |
| 分子式 | C32H29N5O2 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| 参考文献 | Graffet al (2005) The protein kinase Cβ-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts. Cancer Res. 65 7462. PMID: 16103100. Teicheret al (2001) Antiangiogenic and antitumor effects of a protein kinase Cβ inhibitor in human HT-29 colon carcinoma and human CaKi1 renal cell carcinoma xenografts. Anticancer Res. 21 3175. PMID: 11848470. |