| 货号 | 0792/50 |
| 别名 | 2-(2-Ethyl-2,3-dihydro-2-benzofuran |
| 供应商 | Tocris |
| 生物活性 | Potent, highly selective α2 adrenoceptor antagonist and imidazoline I1 receptor ligand (pKi values are 7.87, 7.42, 5.74, 7.28 and < 5 for α2A,α2B,α2C, I1, and I2 receptors respectively). Promotes insulin secretion, at a site distinct from I1 or I2 (the putative I3receptor)in vitroandin vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 252.74 |
| 分子式 | C13H16N2O.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| CAS号 | 89197-00-2 |
| 参考文献 | Mayer and Taberner (2002) Effects of the imidazoline ligands efaroxan and KU14R on blood glucose in the mouse. Eur.J.Pharmacol. 454 95. PMID: 12409010. Eglenet al (1998) 'Seeing through a glass darkly': casting light on imidazoline 'I' sites. TiPS 19 381. PMID: 9786027. Olmoset al (1994) Imidazolines stimulate release of insulin from RIN-5AH cells independently from imidazoline I1 and I2 receptors. Eur.J.Pharmacol. 262 41. PMID: 7813577. Chapleoet al (1984) α-Adrenoceptor reagents 2. Effects of modification of the 1,4-benzodioxan ring system on α-adrenoceptor activity. J.Med.Chem. 27 570. PMID: 6143826. |