| 货号 | 16860-10mg |
| 描述 | Swainsonine is an indolizidine alkaloid naturally found in certain plants including locoweed that inhibits N-linked glycoside hydrolases, preventing the processing of asparagine-linked glycoproteins. It reversibly inhibits lysosomal α-mannosidase and Golgi α-mannosidase II (IC50 = 0.2 μM).1 Swainsonine is used to study the role of N-linked glycosylation in cellular processes and has been shown to have antiproliferative and antimetastatic effects on cancer cells in culture and in mice.2,3,4 The inhibition of α-mannosidase activity in lysosomes produces an accumulation of partially-processed oligosaccharides and glycoproteins, giving rise to lysosomal storage disease. Swainsonine toxicity in herbivores results in a condition known as locoism, characterized by hyperactivity, aggression, stiff and clumsy gait, low head carriage, salivation, seizures, and apparent blindness, culminating in increased miscoordination, weakness and death. |
| 别名 | Tridolgosir; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Tulsiana, D.R.P.,Broquist, H.P., and Touster, O. Marked differences in the swainsonine inhibition of rat liver lysosomal α-D-Mannosidase, Rat Liver Golgi Mannosidase II, and Jack Bean α-D-Mannosidase. Archives of Biochemistry and Biophysics 236, 427-434 (1985). 2.Dennis, J.W.,Koch, K.,Yousefi, S., et al. Growth inhibition of human melanoma tumor xenografts in athymic nude mice by swainsonine. Cancer Research 50, 1867-1872 (1990). 3.Reddy, B.V.V.G., and Kalraiya, R.D. Sialilated β1,6 branched N-oligosaccharides modulate adhesion, chemotaxis, and motility of melanoma cells: Effect on invasion and spontaneous metastasis properties. Biochimica et Biophysica Acta 1760, 1393-1402 (2006). 4.Sun, J.Y.,Zhu, M.Z.,Wang, S.W., et al. Inhibition of the growth of human gastric carcinoma in vivo and in vitro by swainsonine. Phytomedicine 14, 353-359 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 173.2 |
| 分子式 | C8H15NO3 |
| CAS号 | 72741-87-8 |
| 稳定性 | ≥ 2 years |
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