Tauro-β-muricholic Acid (sodium salt)
货号：
20289-5mg 基本售价：
8400.0 元 规格：
5 mg
产品信息
概述| 货号 | 20289-5mg |
| 描述 | Tauro-β-muricholic acid (TβMCA) is a potent competitive and reversible antagonist of the farnesoid X receptor (FXR) (IC50 = 40 µM) that binds bile acids.1 TβMCA accumulates in germ-free mice under normal conditions but is reduced after colonization with feces from a human donor.1,2 TβMCA is increased in the intestines of mice resistant to high-fat diet-induced obesity, fatty liver, and diabetes.3 |
| 别名 | Tauro-β-muricholate;TβMCA; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sayin, S.I.,Wahlström, A.,Felin, J., et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab. 17(2), 225-235 (2013).
2.Wahlström, A.,Kovatcheva-Datchary, P.,Ståhlman, M., et al. Induction of farnesoid X receptor signaling in germ-free mice colonized with a human microbiota. J. Lipid. Res. 58(2), 412-419 (2017).
3.Qi, Y.,Jiang, C.,Cheng, J., et al. Bile acid signaling in lipid metabolism: Metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice. Biochim Biophys. Acta. 1851(1), 19-29 (2015).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 537.7 |
| 分子式 | C26H44NO7S • Na |
| CAS号 | 145022-92-0 |
| 稳定性 | ≥ 2 years |
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