Phortress
货号：
15342-50mg 基本售价：
8400.0 元 规格：
50 mg
产品信息
概述| 货号 | 15342-50mg |
| 描述 | The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that promotes the expression of phase I and II xenobiotic chemical metabolizing enzyme genes, including the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1A2. Phortress is a lysyl amide prodrug of the benzothiazole 5-fluoro 203 (Item No. 17677), a high affinity AhR ligand that elicits antitumor activity by inducing transcription of CYP1A1, which leads to the formation of DNA adducts and cell cycle arrest.1,2 Phortress rapidly reverts to 5-fluoro 203 in carcinoma cell lines, resulting in significant growth inhibition at nanomolar concentrations.2 At 20 mg/kg, phortress can suppress the growth of breast and ovarian xenografts in vivo.2 |
| 别名 | NSC 710305; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bradshaw, T.D.,Chua, M.S.,Browne, H.L., et al. In vitro evaluation of amino acid prodrugs of novel antitumour 2-(4-amino-3-methylphenyl)benzothiazoles. British Journal of Cancer 86, 1348-1354 (2002).
2.Bradshaw, T.D. and Westwell, A.D. The development of the antitumour benzothiazole prodrug, Phortress, as a clinical candidate. Current Medicinal Chemistry 11, 1241-1253 (2004).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 459.4 |
| 分子式 | C20H23FN4OS • 2HCl |
| CAS号 | 328087-38-3 |
| 稳定性 | ≥ 2 years |
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