| 货号 | 14965-5mg |
| 描述 | Furin is a proprotein convertase, converting precursor proteins to functional proteins within the Golgi/trans-Golgi secretory pathway. Furin inhibitor I is a selective, irreversible, and cell-permeable competitive inhibitor of proprotein convertases, including furin/SPC1 (Ki = ~1 nM), SPC2/PC2 (Ki = 0.36 nM), SPC3/PC1/PC3 (Ki = 2.0 nM), SPC4/PACE4 (Ki = 3.6 nM), SPC6/PC5/PC6, and SPC7/LPC/PC7/PC8 (Ki = 0.12 nM).1,2 Because furin activates viral glycoproteins, this inhibitor is a useful antiviral agent.3 In addition, it inhibits furin-dependent pro-MMP-2 activation in mononuclear inflammatory cells.4 |
| 别名 | Decanoyl-Arg-Val-Lys-Arg-CMK; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Angliker, H.,Wikstrom, P.,Shaw, E., et al. The synthesis of inhibitors for processing proteinases and their action on the Kex2 proteinase of yeast. Biochemistry Journal 293(1), 75-81 (1993). 2.Fugère, M.,Limperis, P.C.,Beaulieu-Audy, V., et al. Inhibitory potency and specificity of subtilase-like Pro-protein convertase (SPC) prodomains. The Journal of Biological Chemisty 277(10), 7648-7656 (2002). 3.Wanyiri, J.W.,OConnor, R.,Allison, G., et al. Proteolytic processing of the Cryptosporidium glycoprotein gp40/15 by human furin and by a parasite-derived furin-like protease activity. Infection and Immunity 75(1), 184-192 (2007). 4.Stawowy, P.,Meyborg, H.,Stibenz, D., et al. Furin-like proprotein convertases are central regulators of the membrane type matrix metalloproteinase-pro-matrix metalloproteinase-2 proteolytic cascade in atherosclerosis. Circulation 111(21), 2820-2827 (2005). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 744.4 |
| 分子式 | C34H66ClN11O5 |
| CAS号 | 150113-99-8 |
| 稳定性 | ≥ 2 years |
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