| 货号 | 12028-500mg |
| 描述 | Resveratrol is a potent phenolic antioxidant found in the skin of grapes and red wine that has anti-proliferative, anti-inflammatory, and cardioprotective properties.1 Oxyresveratrol is a naturally occurring analog of resveratrol found in mulberry wood. It effectively scavenges H2O2, NO (IC50 = 45.3 μM), and the artificial free radical 2,2-diphenyl-l-picrylhydrazyl (IC50 = 28.9 μM).2 At 10 mg/kg, oxyresveratrol acts as a neuroprotectant, reducing brain infarct volume and reducing cytochrome c release and caspase-3 activation in an in vivo model of stroke.3 Oxyresveratrol also has depigmenting effects by effectively inhibiting tyrosinase activity, which catalyzes the rate-limiting step in synthesizing melanin pigments (IC50s = 1.2 and 52.7 μM in mushroom and mouse melanoma B-16 cells, respectively).4 It is 32-fold more potent than kojic acid, a depigmenting agent used in cosmetic materials with skin-whitening effects and medical agents used to treat hyperpigmentation disorders.4 |
| 别名 | trans-2,3,4,5-Tetramethoxystilbene; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Rotondo, S.,Rajtar, G.,Manarini, S., et al. Effect of trans-resveratrol, a natural polyphenolic compound, on human polymorphonuclear leukocyte function. British Journal of Pharmacology 123, 1691-1699 (1998). 2.Lorenz, P.,Roychowdhury, S.,Engelmann, M., et al. Oxyresveratrol and resveratrol are potent antioxidants and free radical scavengers: Effect on nitrosative and oxidative stress derived from microglial cells. Nitric Oxide: Biology and Chemistry 9(2), 64-76 (2003). 3.Andrabi, S.A.,Spina, M.G.,Lorenz, P., et al. Oxyresveratrol (trans-2,3,4,5-tetrahydroxystilbene) is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia. Brain Research 1017, 98-107 (2004). 4.Kim, Y.M.,Yun, J.,Lee, C.K., et al. Oxyresveratrol and hydroxystilbene compounds. Inhbitory effect on tyrosinase and mechanism of action. J. Biol. Chem. 277(18), 16340-16344 (2002). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 244.2 |
| 分子式 | C14H12O4 |
| CAS号 | 29700-22-9 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |