| 货号 | 9001935-10mg |
| 描述 | (−)-Blebbistatin (Item No. 13013) is a selective, cell-permeable inhibitor of non-muscle myosin II ATPases that blocks apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells.1,2 However, prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications.3,4 To circumvent this issue, a nitro group analog of (−)-blebbistatin, (S)-nitro-blebbistatin (Item No. 13891) was developed to improve stability under prolonged irradiation at 450-490 nm.5 (R)-nitro-Blebbistatin is a nitro group-containing blebbistatin analog with the same stereochemistry as the inactive (+)-blebbistatin (Item No. 13165) enantiomer. |
| 别名 | R-(−)-7-Desmethyl-8-nitro Blebbistatin; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Abe, M.,Ho, C.H.,Kamm, K.E., et al. Different molecular motors mediate platelet-derived growth factor and lysophosphatidic acid-stimulated floating collagen matrix contraction. The Journal of Biological Chemisty 278(48), 47707-47712 (2003). 2.Straight, A.F.,Cheung, A.,Limouze, J., et al. Dissecting temporal and spatial control of cytokinesis with a myosin II inhibitor. Science 299(5613), 1743-1747 (2003). 3.Kolega, J. Phototoxicity and photoinactivation of blebbistatin in UV and visible light. Biochem. Biophys. Res. Commun. 320(3), 1020-1025 (2004). 4.Sakamoto, T.,Limouze, J.,Combs, C.A., et al. Blebbistatin, a myosin II inhibitor, is photoinactivated by blue light. Biochemistry 44(2), 584-588 (2005). 5.Lucas-Lopez, C.,Patterson, S.,Blum, T., et al. Absolute stereochemical assignment and fluorescence tuning of the small molecule tool, (−)-blebbistatin. European J. Org. Chem. 2005(9), 1736-1740 (2005). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 323.3 |
| 分子式 | C17H13N3O4 |
| CAS号 | 1217619-62-9 |
| 稳定性 | ≥ 2 years |
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