Sp-5,6-dichloro-cBIMPS (sodium salt)
货号：
18822-5mg 基本售价：
8358.0 元 规格：
5 mg
产品信息
概述| 货号 | 18822-5mg |
| 描述 | Sp-5,6-dichloro-cBIMPS is a benzimidazole monophosphorothioate that acts as a potent activator of protein kinase A (PKA; Ki = 30 nM).1 It is selective for PKA over PKG (Ki = 10 µM).1 Sp-5,6-dichloro-cBIMPS is also resistant to degradation by cyclic nucleotide phosphodiesterases.1,2 It displays good cell permeability and prevents the aggregation of platelets stimulated with thrombin (Item No. 13188).1 |
| 别名 | Sp-5,6-DCI-cBIMPS; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sandberg, M.,Butt, E.,Nolte, C., et al. Characterization of Sp-5,6-dichloro-1-β-D-ribofuranosylbenzimidazole-3,5-monophosphorothioate (Sp-5,6-DCl-cBiMPS) as a potent and specific activator of cyclic-AMP-dependent protein kinase in cell extracts and intact cells. Biochemistry Journal 279, 521-527 (1991).
2.Jäger, R.,Russwurm, C.,Schwede, F., et al. Activation of PDE10 and PDE11 phosphodiesterases. The Journal of Biological Chemisty 287(2), 1210-1219 (2012).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 419.1 |
| 分子式 | C12H10Cl2N2O5PS • Na |
| CAS号 | 142439-96-1 |
| 稳定性 | ≥ 2 years |
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